Cefazolin for injection and other antibacterial drugs, Cefazolin for injection should be A Pharmacy Bulk Package is sterile dosage form for parenteral use that. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefazolin for Cefazolin for Injection, USP is a semi-synthetic cephalosporin for parenteral administration. .. For IV Administration: See package insert. Page 2 of PRODUCT MONOGRAPH. Pr. Cefazolin for Injection USP. THERAPEUTIC CLASSIFICATION. Antibiotic. ACTION AND CLINICAL.

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Treatment should be given only if clearly needed. If possible, avoid coadministration. Cefazolin is ancec excreted unchanged into the urine via glomerular filtration and tubular secretion, although tubular secretion appears to be less important for renal clearance of cefazolin than for cephalothin. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including cefazolin, and may range in severity inseert mild to life-threatening.

Bone and Joint Infections Due to S. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.

Neonates younger than 32 weeks gestation and 0 to 13 days. Additionally, certain cephalosporins cefotetan, cefoperazone, cefamandole are inaert with prolongation of the prothrombin time due to the methylthiotetrazole MTT side chain at the R2 position, which disturbs the synthesis of vitamin K-dependent clotting factors in the liver. An anaphylactic response to both classes of drugs is possible.

Clinical practice guidelines recommend cefazolin monotherapy for cardiothoracic, gastrointestinal, biliary tract, hernia repair, clean head and neck with prosthesis, neurosurgical, urogynecology, orthopedic, vascular, certain transplantation, and plastic surgery procedures.

Intermittent hemodialysis For adult patients, mg to 1 g IV every 24 hours is recommended. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting with diarrhea following antibacterial administration. Reconstitution Reconstitute powder with Sterile Water for Injection. If diarrhea develops during therapy, the drug should be discontinued. Studies of cord blood andef prompt transfer of cefazolin across the placenta.


Cardiac patients that are considered to be at highest risk include those with prosthetic cardiac valves or prosthetic material used for cardiac valve repair, previous infective endocarditis, select types of congenital heart disease CHDand cardiac transplantation with valvulopathy. ANCEF is effective in the eradication of streptococci from the nasopharynx; however, data establishing the efficacy of ANCEF in the pavkage prevention of rheumatic fever are not available.

Moderate Nephrotoxicity associated with cephalosporins may be potentiated by concomitant furosemide therapy. Reconstituted solutions may range in color from pale yellow to yellow without a change in potency. For the treatment of urinary tract infection UTI.

ADD-Vantage vials should be reconstituted immediately before administration; however, the solution is stable for 24 hours at room temperature. In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted.

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No overall differences in safety or effectiveness of cefazolin were observed between the older adult and younger adults in clinical trials. Unlike cephalothin, cefazolin is not hepatically metabolized. According to OBRA, use of antibiotics should be limited to confirmed or suspected bacterial infections.

Thaw frozen container at room temperature or under refrigeration. Cefazolin should be used with caution in patients with renal impairment or renal failure since the drug is eliminated via renal mechanisms. Guidelines recommend cefazolin for 4 weeks for native valve endocarditis NVE and for 6 weeks for prosthetic valve endocarditis PVE caused by S.

The perioperative use of ANCEF may also be effective in surgical patients in whom infection at the operative site would present a serious risk e. The manufacturer recommends that cefazolin should be used with caution during breast feeding and the benefits versus risks should be considered. Repeat dose intraoperatively 4 hours after preoperative dose if surgery still in progress. Clinical practice guidelines suggest 2 g IV, and for patients weighing kg or more, 3 g IV. A false-positive reaction for glucose in the urine has been observed in patients receiving cephalosporins, such as cefazolin, and using Benedict’s solution, Fehling’s solution, or Clinitest tablets for urine glucose testing.

Intravenous Administration Direct bolus injection: Cefazolin is excreted renally; because geriatric patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function. Cefazolin does not reach therapeutic levels within the CSF. Like all beta-lactam antibiotics, cefazolin’s ability to interfere with PBP-mediated cell wall synthesis ultimately leads to cell lysis.


Lysis is mediated by bacterial cell wall autolytic enzymes i. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Cephalosporins should be used cautiously in patients with a preexisting coagulopathy e. Though vastly different, these tools share a basic truth.

Guidelines recommend cefazolin as an alternate therapy for highly penicillin-susceptible streptococcal infections; treat for 4 weeks for native valve endocarditis NVE and for 6 weeks or prosthetic valve endocarditis PVE. Thus, the intrinsic activity of cefazolin as well as other cephalosporins and penicillins against a particular organism depends on their ability to gain access to and bind with the necessary PBP. If particulate matter is evident in reconstituted fluids, the drug solutions should be discarded.

Most strains of indole positive Proteus Proteus vulgarisEnterobacter spp. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries e. The serum half-life for cefazolin is approximately 1. Baxter Healthcare Corporation does not endorse and is not responsible for the accuracy, content, practices or standards of any non-Baxter sources. L60 Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.

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Prescribing practices are as unique as patient populations, and pharmacies have varying levels of nutrition compounding capability and expertise. Disclaimer The authors make no claims of the accuracy of the pacage contained herein; and these suggested doses are not a substitute for clinical judgment.

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