AVONEX PACKAGE INSERT PDF

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1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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Discontinue riluzole if clinical signs of liver dysfunction are present. If you are a female of childbearing age and are sexually active, you should use birth control during treatment with AVONEX. Moderate The concomitant use of interferons and anti-retroviral protease inhibitors should be done with caution as both can cause hepatotoxicity.

Nausea, vomiting or diarrhoea. Major The concomitant use of interferons and nevirapine should be done with caution as both can cause hepatotoxicity. Do not give on two consecutive days. Contact MS ActiveSource for more information —— If a patient does become pregnant while receiving interferon therapy, she should be made aware of the risk.

You may need urgent medical attention or hospitalisation.

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Although interferon beta-1a is not directly cardiotoxic, serious cardiac adverse events have been reported in patients without a prior history of cardiac disease see Adverse Reactions.

Rapid addition of the diluent may cause foaming, making it difficult to withdraw the solution. Use with caution in patients with hepatic disease. Patients should be monitored for signs of these disorders.

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Avonx, do not inject into skin that is red, irritated, bruised, or infected. It is thought that INF-G stimulates cytotoxic T-cells and induces macrophages to produce proteinases that degrade the myelin sheath around the spinal cord. Pacmage, a small number of nursing mothers receiving interferon beta-1a reported no adverse effects in their partially breast-fed infants, and the amount of interferon beta-1a excreted into breast milk appeared to be insignificant.

This may increase insret chance of you getting an unwanted side effect.

Ask your doctor, MS nurse or pharmacist to answer any questions you may have. If the goal dose is 22 mcg, in inswrt 1 to 2 administer 4.

Hold Pen at 90 degree angle to the injection site. Soreness, redness or bruising at the injection site.

Patients should be advised to avoid drinking alcohol to reduce the chance of injury to the liver during interferon beta treatment. Shaking can damage this medicine.

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Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Talk to your doctor if you are interested in whether this is appropriate for you. If it has expired or is damaged or looks differently than it should, return it to your pharmacist for disposal.

Autoimmune disease of multiple target organs has been reported during interferon beta-1a therapy, including idiopathic thrombocytopenia, thyroid disease hyperthyroidism or hypothyroidismand rare cases of autoimmune hepatitis. Nevirapine may cause liver damage in the context of hypersensitivity reactions or by direct toxic effects.

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Patients with chronic, cirrhotic HCV co-infected with HIV receiving antiretroviral agents and alpha interferons appear to be at increased risk for hepatic decompensation e. Used to treat epilepsy prevent fits. After being taught to self-inject, you should refer to the leaflet in the pack for step-by-step instructions about how to prepare pac,age inject AVONEX.

Avonex Pen should be injected into the upper, outer thigh.

Unusual bleeding or bruising. You may need urgent medical attention. Refer to the Patient Medication Guide for detailed instructions for preparing and giving a dose. No cases of transmission of viral diseases or CJD have ever been identified for albumin. Use of interferons during pregnancy should be avoided due to the risk of spontaneous abortion.

In contrast, none of the placebo recipients and The drug should not be used with interferons, which are associated with a potential for serious ophthalmic effects e. As an alternative, to reduce packate incidence and severity of flu-like symptoms, treatment may be packwge with an IM dose of 7.