Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.
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Penicillamine-induced elastosis of the mucosal lip.
Patient serpihinosa on presentation to elasgosis institution with erythematous annular plaques on her neck. Related articles D-penicillamine elastosis perforans serpiginosa lumpy-bumpy elastic fibers. Indian J Dermatol ; Hofmann et al 4 reported tazarotene’s effectiveness in the treatment of congenital ichthyoses in an open, intraindividually controlled, half-side investigation. Many elastic fibers were noted to be pushing through epidermal channels Figure 1a finding that was consistent with the clinical diagnosis of elastosis perforans serpiginosa EPS.
Penicillamine-induced elastosis perforans serpiginosa with abnormal “lumpy-bumpy” elastic fibers in lesional and non-lesional skin.
In the transepidermal channel, and particularly in its lower part, basophilic degeneration mass consisting of keratinocytes, remainings of crumbled inflammatory cells and elastic fibers can be detected. Both patients continue to use tazarotene daily for intermittent courses serpiglnosa their disease flares.
D-penicillamine induced elastic fiber alteration may not always manifest clinically as EPS. D-penicillamine induced EPS has a distinctive histopathologic feature – serrated appearance of elastic fibers due to perpendicular budding from their surface giving a “lumpy-bumpy” look. Author information Article notes Copyright and License information Disclaimer. However, further studies are needed to evaluate the effectiveness of such topical therapy for treating EPS.
Tazarotene may have comedolytic properties that allow for the unplugging of transepidermal pores in this disease. In the biopsies an increased amount elasotsis elastic fibers can be found, both just underneath the epidermis and in the reticular layer of the dermis. National Center for Biotechnology InformationU. serpiinosa
The histopathologic pperforans revealed the thick epidermis, typical of EPS, and a transepithelial narrow channel of a wavy configuration Figure 2 A. The patient was treated unsuccessfully with cryotherapy approximately 6 times; high-potency topical corticosteroids, including clobetasol and halobetasol, for 6 weeks; topical 0. Though numerous treatment modalities have been described in the literature, most are not very effective.
Moreover, attempts to treat Serpiginpsa with oral isotretinoin, local corticosteroid injections, electrocoagulation, cryotherapy as well as UVB irradiation were performed but the effect was poor [ 34 ]. Acquired disorders of elastic tissue: Get free access to newly published articles.
Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. None, Conflict of Interest: Imiquimod therapy for elastosis perforans serpiginosa. In addition to a marked increase in the amount and thickness of papillary dermal elastic tissue, a chronic inflammatory infiltrate containing lymphocytes, macrophages, or perforns giant cells may be present in the dermis at the sites of perforation.
D-penicillamine-induced elastosis perforans serpiginosa in a child with juvenile rheumatoid arthritis. On physical examination, she was noted to have erythematous annular and arcuate keratotic plaques on the anterior aspect of her neck and right arm Figure 2. While calcinosis cutis, granuloma annulare, Tinea corporisannular sarcoidosis, and porokeratosis of Mibelli perfoorans present with clinically similar features, these disorders are easily distinguished by histological examination.
YAG, and dye lasers. Open in a separate window.
The D-penicillamine therapy had been discontinued 2 months before her presentation to our clinic. It appears to be more common in males than females ratio 4: Usually it spontaneously resolves without complications after a few years.
There is no cure for EPS.