Erythema elevatum diutinum (EED) is a rare, chronic dermatosis that is characterized by red–violet to red–brown papules, plaques, and. Erythema elevatum diutinum (EED) is a chronic form of leukocytoclastic vasculitis consisting of violaceous, red-brown, or yellowish papules. Erythema elevatum diutinum. Authoritative facts about the skin from DermNet New Zealand.

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The lesions are persistent and symmetrically distributed on extensor surfaces, particularly in the joints of the extremities. Although the etiology of EED is unknown, circulating immune complexes, with repeated deposition, associated inflammation, and partial healing are thought to represent the underlying pathogenesis.

Extracutaneous symptoms include arthralgia, fever, or other constitutional symptoms.

These lesions are usually symmetrically distributed on the extensor surfaces of the extremities. Furthermore, the initiation of EED may occur via activation of cytokines interleukin-8which causes selective recruitment of leukocytes to blood vessels.

Recently, it has been added to the group elsvatum specific dermatoses that are associated with HIV. Accessed December 31st, Dapsone was used in the treatment of this patient, and partial regression of the elevatuum was achieved within 15 days, even before antiretroviral therapy was prescribed.

Polymorphonuclear cells, macrophages, histiocytes, and eosinophils may surround the blood vessels. Erythema elevatum diutinum–a report of two unusual patients. Neurotoxoplasmosis of the central nervous system was diagnosed by eritwma of computed tomography of the head, and the patient was hospitalized for 15 days for treatment. Infections from group B streptococci, HIV, syphilis, and viral hepatitis are commonly associated with EED as well as autoimmune conditions, such as celiac disease, Crohn disease, systemic lupus erythematosus and rheumatoid arthritis.


This cutaneous condition elevatim is a stub. Sulfone therapy in the treatment of leukocytoclastic vasculitis. Sign up for our Email Newsletters. It is probable that immune complex deposition occurs in vessel walls, 1 secondary to streptococcal infections 4 and hematological 3,5 and autoimmune diseases.

Click here for patient related inquiries. Erythema gyratum repens Necrolytic migratory erythema. An earlier onset occurs more often in the setting of HIV infection.

However, in some cases after evolving over a year period it may spontaneously clear. Continuing navigation will be considered as eoevatum of this use.

Eritema elevatum diutinum as a differential diagnosis of rheumatic diseases: case report.

Typically, the lesions are asymptomatic, but there have been reports of patients who experienced pruritus and burning or tingling sensations, especially early in erittema disease course. StatPearls Publishing ; Jan. It presents predominantly in males, in the fourth to sixth decade of life. One month after diagnosing HIV infection, the patient presented a neurological condition of right-side motor impairment.

Erythema elevatum diutinum presenting with a giant annular pattern.

Eritema elevatum diutinum | Actas Dermo-Sifiliográficas

J Hand Surg Am. After laboratory studies erythrocite sedimentation rate, C reactive protein, protein electrophoresis, serological test and biopsy of lesions we confirmed a diagnosis of erythema eevatum diutinum.

Review Erythema elevatum diutinum: Report of three elevatu. On exam, lesions of EED present as red—brown, yellowish, or violaceous papules, plaques, or nodules. The exception includes ocular abnormalities such as scleritis, uveitis, autoimmune keratolysis, and peripheral keratitis. Co-occurring diseases include monoclonal paraproteinemias, lymphoproliferative disorders, chronic infection, autoimmune conditions, and connective tissue diseases.


We reviewed the clinical characteristics, histologic, epidemiologic and associated features of the process.

Erythema, Elevatum Diutinum – StatPearls – NCBI Bookshelf

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. April 13, Accepted: It is generally associated with autoimmune, neoplastic and infectious processes.

Show details Treasure Island FL: It is relatively non-toxic and can be used in the treatment of neutrophil-driven disorders, with fewer side effects than dapsone. Sign in via Shibboleth. The pathogenesis of EED is not entirely clear; however, the prevailing and traditional theories are based on immune complex deposition within vessel walls, complement fixation, inflammation, and subsequent vascular destruction.

The fibrosis of late lesions is most likely a result of chronic dermal injury of leukocytoclastic vasculitis. It is also ineffective in nodular lesions, due to the fibrosis of the lesions.

J Am Acad Dermatol. Otherwise it is hidden djutinum view. New author database being installed, click here for details. Other therapies include NSAIDs, niacinamide, tetracyclines, chloroquine, colchicine, and plasmapheresis. In general, their overall condition is not compromised. The male-to-female ratio is approximately equal, and no racial predilection has been observed. EED may occur in any age group, but patients are typically between 30 and 60 years old.