LINKAGE OF EARLY-ONSET FAMILIAL BREAST CANCER TO CHROMOSOME 17Q21 PDF

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PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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Linkage of early-onset familial breast cancer to chromosome 17q This article has been cited by other articles chromoslme PMC. Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.

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Estimating the power of linkage analysis in 117q21 breast cancer. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. National Center for Biotechnology InformationU.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Segregation and linkage analysis of nine Utah breast cancer pedigrees. Closing in on a breast cancer gene on chromosome 17q. Support Ramilial Support Center. Strategies for multilocus linkage analysis in humans. Genetic epidemiology of breast cancer in Britain.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Inheritance of proliferative breast disease in breast cancer kindreds. Chdomosome Data Supplementary Materials. Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.

A new statistical test for linkage heterogeneity. Genetic epidemiology of breast cancer: Author information Copyright and License information Disclaimer. Genetic analysis of breast cancer in the cancer and steroid hormone study.

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Linkage of early-onset familial breast cancer to chromosome 17q

Am J Hum Genet. See Am J Hum Genet. Familial breast-ovarian cancer locus on chromosome 17qq If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for earlyy-onset sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

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Linkage of early-onset familial breast cancer to chromosome 17q21.

Please review our privacy policy. Inheritance of human breast cancer: There is probably more than one gene for inherited breast cancer, but ot may not be due to age at disease onset. However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested.